Systemic inhibition of sclerostin for treatment of osteoporosis and bone healing
β Scribed by W. Scott Simonet
- Book ID
- 116323668
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 108 KB
- Volume
- 47
- Category
- Article
- ISSN
- 8756-3282
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Sclerostin is the product of the __SOST__ gene. Lossβofβfunction mutations in the __SOST__ gene result in a highβboneβmass phenotype, demonstrating that sclerostin is a negative regulator of bone mass. Primarily expressed by osteocytes in bone, sclerostin is reported to bind the LRP5/6
## Abstract Therapeutic enhancement of fracture healing would help to prevent the occurrence of orthopedic complications such as nonunion and revision surgery. Sclerostin is a negative regulator of bone formation, and treatment with a sclerostin monoclonal antibody (SclβAb) results in increased bon