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Systemic antineutrophil cytoplasmic antibody vasculitis in a patient with chronic lymphocytic leukemia: Quite a rare diagnosis

✍ Scribed by Gülsüm Emel Pamuk; Mehmet Sevki Uyanık; Muzaffer Demir; Emre Tekgündüz; Burhan Turgut; Mehmet Soy

Book ID
104040260
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
98 KB
Volume
31
Category
Article
ISSN
0145-2126

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✦ Synopsis

There might be rheumatic manifestations of malignant diseases, especially those of the hematological type. Until now, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis in chronic lymphocytic leukemia (CLL) has been reported on only very few occasions. Here, we present our patient with Rai stage II CLL who came to us with constitutional symptoms. She turned out to have hematuria with dysmorphic erythrocytes and developed hemoptysis. She had pulmonary-renal syndrome and was diagnosed with p-ANCA positive microscopic polyangiitis. She is currently using prednisolone and cyclophosphamide and undergoing regular hemodialysis. Constitutional symptoms in patients with hematological malignancies should make the physicians consider systemic vasculitis after exclusion of diseaserelated complications.

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