The preparation of t3C-labeled ribonucleosides starting from D-[t3C~]glucose in 45% overall yield is described. The key of this short synthetic way is the dehomologation of di-O-isopropylidene hexofuranose 2 with periodic acid and NaBI-I4 that afforded stereoselectively the labeled ribofuranose deri
Systematic synthesis of specifically 13C2H-labeled nucleosides from [ul-13C6]-d-glucose
β Scribed by Akira (Mei) Ono; Toko Shiina; Akira Ono; Masatsune Kainosho
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 244 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
A systematic approach, which combines previously reported reactions with appropriate modifications, was established for preparing a variety of selectively deuterated nucleosides from glucoseβ’ We have developed a systematic method of synthesizing specifically deuterated nucleosides from glucose.
π SIMILAR VOLUMES
D-(1,5,6-13C3)Glucose (7) has been synthesized by a six-step chemical method. D-(1,2-13C2)Mannose (1) was converted to methyl D-(1,2-13C2)mannopyranosides (2), and 2 was oxidized with Pt-C and O2 to give methyl D-(1,2-13C2)mannopyranuronides (3). After purification by anion-exchange chromatography,
## Abstract Efficient methods for synthesising Lβ[methyβ ^13^C]methionine from [^13^C]iodomethane and Lβmethionine, and Lβ[3,4β^13^C~2~] methionine from [^13^C~2~]ethene, are described; the preparation of [3,3β^2^H~2~]methionine and [2,3,3β^2^H~3~]methionine from methionine by an exchange method is
## Abstract Tumoral pancreatic islet cells of the RIN5mF line were incubated for 120 min in media prepared in ^2^H~2~O and containing Dβ[1β^13^C]glucose, and Dβ[2β^13^C]glucose, and Dβ[6β^13^C]glucose. The generation of C~2~β and C~3~β deuterated lactic acid was assessed by ^13^C NMR. The interpret
## Abstract The synthesis of [1,3,5β^13^C~3~]β and [2,4,6,7β^13^C~4~]benzoic acid (5a and 5b) from [2β^13^C]β and [3β^13^C]sodium pyruvate (1a and 1b), for __in vitro__ and __in vivo__ tracer studies using ^13^C nuclear magnetic resonance (NMR) spectroscopy, is reported. After condensation of 1 to