Systematic study of substance P analogs
β Scribed by WANG, JIAN-XIN ;BRAY, ANDREW M. ;DIPASQUALE, ANGELA J. ;MAEJI, N. JOE ;GEYSEN, H. MARIO
- Book ID
- 115099565
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 628 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0367-8377
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π SIMILAR VOLUMES
Structure-activity relationships of cyclic substance P (SP) analogs were extensively studied in our laboratories utilizing the new concept of backbone cyclization. Employing the C-terminal hexapeptide SP6\_ II, we examined the influence of chemical changes in peptides containing backbone-to-amino-en
## Synopsis 'H-nmr studies of [pG1u6]SPs~1, [gpG1u6,mPhe7]SP6 11, and [pGlu6,N-CH3Phe7]SPg~~ in DMSO-ds reveal characteristic chemical shifts, 3 5 ~~ a ~~, temperature dependence, as well as deuterium exchange half-times. Marked similarities are revealed for the two first analogs, whereas the N-me