Systematic analysis of in vitro chemosensitivity and mib-1 expression in molecular breast cancer subtypes
β Scribed by Cornelia Liedtke; Jens Packeisen; Kenneth R. Hess; Ulf Vogt; Ludwig Kiesel; Christian Kersting; Eberhardt Korsching; Burkhard Brandt; Horst Buerger
- Book ID
- 116430858
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 273 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0959-8049
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract BRCA1 is a multifunctional tumorβsuppressive protein. Many functional aspects of BRCA1 are not fully understood. We used a shRNA approach to probe the function of BRCA1 in human breast cancer cells. Knocking down BRCA1 expression by shRNA in the wildβtype BRCA1 human breast cancer MCFβ7
## Abstract Breast carcinomas are characterized by DNA copy number alterations (CNAs) with biological and clinical significance. This explorative study integrated CNA, expression, and germline genotype data of 112 earlyβstage breast cancer patients. Recurrent CNAs differed substantially between tum