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Synthèse d'homologues de la lysine-vasopressine et de l'oxytocine contenant une séquence His-Sér ou Sér-His en position N-terminale

✍ Scribed by S. T. Guttmann; R. A. Boissonnas

Publisher
John Wiley and Sons
Year
1962
Tongue
German
Weight
822 KB
Volume
45
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

(His‐Ser‐Cys)^1^‐lysine‐vasopressin, (Ser‐His‐Cys)^1^‐lysine‐vasopressin, (His‐Ser‐Cys)^1^‐oxytocin and (Ser‐His‐Cys)^1^‐oxytocin have been synthesized by condensing dipeptide azides with nonapeptides. The first peptide was also prepared by reacting a pentapeptide azide with an hexapeptide. It exhibits a noteworthy ACTH‐releasing activity in vivo and a better specificity than lysine‐vasopressin.

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