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Synthèse de dihydro-6,7-imidazo[1,2−a]triazines-1,3,5 disubstituées

✍ Scribed by R. Hinkens; R. Promel; R. H. Martin

Publisher
John Wiley and Sons
Year
1961
Tongue
German
Weight
664 KB
Volume
44
Category
Article
ISSN
0018-019X

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✦ Synopsis

Four 2,4‐disubstituted 6,7‐dihydro‐imidazo[1,2−a]‐s‐triazines (IV, VII, X and XV) have been synthesized according to the following scheme: (a) monosubstitution of cyanuric chloride (I) with ethanolamine, (b) replacement of the remaining chlorine atomes by suitable groupe, and (c) cyclisation of the 2′‐hydroxy‐ethylamino side chain on one of the adjacent cyclic nitrogen atoms of the s‐triazine nucleus. This last step includes reaction of the 2‐[(2‐hydroxy‐ethyl)‐amino]‐s‐triazines with thionyle chloride or p‐toluenesulfonyl chloride and, with one exception (VIII→IX), heating the resulting 2‐[(2‐chloro‐ethyl)‐amino] derivatives or p‐toluenesulfonic esters in a solvent.

📜 SIMILAR VOLUMES

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## Abstract Alkyl‐5__H__‐6,7‐dihydrocyclopenta[__b__]pyrazines are prepared by condensation of cyclopentenolones with alkylenediamines or of aliphatic α‐diketones with 1,2‐diaminocyclo pentanes. Products so obtained were dehydrogenated using palladium on activated charcoal, or copper chromite. NMR.

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## Abstract A simple and unambiguous synthesis of 2,4‐dihydroxy‐l,3,5‐triazine (VI) has been devised starting from cyanuric chloride. 2,4‐Dihydroxy‐l, 3,5‐triazine is identical with allantoxaidin (IV) obtained by alkaline oxidation of uric acid.