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Synthetic studies towards the total synthesis of tedanolide: formation of the C(13)–C(23) fragment

✍ Scribed by Teck-Peng Loh; Li-Chun Feng

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
76 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

The C(13)-C(23) subunit of tedanolide was obtained using a boron-mediated aldol reaction as the key step to control the C 16 and C 17 stereocenters.

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Synthetic studies towards the group A st
Synthetic studies towards the group A streptogramin antibiotics. Synthesis of the C9–C23 fragment
✍ Chris J Brennan; Jean-Marc Campagne 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 106 KB

A synthesis of the C9-C23 subunit of the group A streptogramin antibiotics is described. The synthesis incorporates a palladium-catalysed sp-sp coupling and a catalytic asymmetric vinylogous Mukaiyama aldol reaction to induce the stereogenic centre at C14.