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Synthetic studies towards the 2-aminopyrimidine alkaloids variolins and meridianins from marine origin

✍ Scribed by Pilar M Fresneda; Pedro Molina *; Santiago Delgado; Juan A Bleda

Book ID: 104210441
Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 121 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)00728-0

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✦ Synopsis

A nine-step synthesis of 9-amino-4-methoxypyrido[3 H ,2 H :4,5]pyrrolo[1,2-c]pyrimidine, a tricyclic ring system present in the marine alkaloids variolins is described. The natural marine products meridianins C±E have been synthesized for the ®rst time starting from N-protected 3-acylindoles.

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