✦ LIBER ✦
Synthetic studies towards halichondramides, and related novel tris-oxazole containing macrolides from marine organisms. A concise route to the keto-triol formyl enamine moiety.
✍ Scribed by Milton J. Kiefel; John Maddock; Gerald Pattenden
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- French
- Weight
- 275 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
A synthesis of the km-trinlfornzyl rrrandrw moiety (3 J irl the marw nretubol~te hnlichondromide (I) is described. The synthesis feamres judiriolrs application of the Evarrs chirul uldol protocol in combinutio~~ with the controlled ring opening ofrhiml a-epoxy alcohol precursor molerules to elaborate the units (5) and (61. A Wadsworrh-Emmons coupling betwetw (51 and (6) next provided (181, which was then elaborated to (3) via the key intermediates ( 19) and ( 21).