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Synthetic Studies toward the Total Synthesis of Swinholide. 1. Stereoselective Construction of the C 19 −C 35 Subunit

✍ Scribed by Keck, Gary E.; Lundquist, Gregory D.


Book ID
127065660
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
451 KB
Volume
64
Category
Article
ISSN
0022-3263

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Synthetic studies toward phorboxazole A.
✍ David R Williams; Michael P Clark; Martin A Berliner 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 250 KB

A stereocontrolled synthesis of two fragments comprising the macrocyclic core of Phorboxazole A is described. The C3-C19 bis-pyran segment is prepared utilizing reiterative enantioselective allylations from homochiral aUylstannanes followed by stereoselective cyclizations. The pentasubstituted tetra