Synthetic studies toward the microtubule-stabilizing agent laulimalide: synthesis of the C1–C14 fragment
✍ Scribed by Geoffry T Nadolski; Bradley S Davidson
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 87 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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A stereocontrolled synthesis of the C15±C27 fragment of laulimalide is described. Key features are a divergent±convergent synthesis from (R)-glycidol, an interesting formation of a trisubstituted double bond via ring closing metathesis with Grubbs' ruthenium catalyst and a site selective protection