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Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials

✍ Scribed by Sandra Gemma; Francesc Martí; Emanuele Gabellieri; Giuseppe Campiani; Ettore Novellino; Stefania Butini


Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
314 KB
Volume
50
Category
Article
ISSN
0040-4039

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## Abstract A facile synthesis of the imidazo[1,5‐__d__]thieno[2,3‐__b__][1,4]thiazine ring system is described. Reaction of 6‐benzyl‐2,3‐dihydro‐1__H__‐thieno[2,3‐__b__][1,4]thiazine‐2‐one (**1**) with potassium __tert__‐butoxide and diethylchlorophosphate gave intermediate **2** which resulted in