𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthetic studies on β-lactam antibiotics. 15. conversion of 7-epicephems into 1-oxacephems

✍ Scribed by Yoshio Hamashima; Tadatoshi Kubota; Koji Ishikura; Wataru Nagata

Publisher
Elsevier Science
Year
1979
Tongue
French
Weight
261 KB
Volume
20
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthetic studies on β-lactam antibiotic
Synthetic studies on β-lactam antibiotics. 19. Synthesis of 3′-nor-type 1-oxacephems
✍ Yoshio Hamashima; Sadao Yamamoto; Tadatoshi Kubota; Katsuya Tokura; Koji Ishikur 📂 Article 📅 1979 🏛 Elsevier Science 🌐 French ⚖ 256 KB

Synthesis of optically active 3'-nor-type 1-oxacephems from 6-APA was described. R-Nitrobenzyl 7B-amino-3-chloro-7a-methoxy-l-oxa-3-cephem-4-carboxylate 39 was also prepared. - et al. 2a described that some 3-norcephalosporins showed antibacterial activity equivalent to naturally occurring cephalo

Synthetic studies on β-lactam antibiotic
Synthetic studies on β-lactam antibiotics. 18. Convenient, stereocontrolled synthesis of 3-methyl 7α-methoxy-1-oxacephems
✍ Tsutomu Aoki; Mitsuru Yoshioka; Yuji Sendo; Wataru Nagata 📂 Article 📅 1979 🏛 Elsevier Science 🌐 French ⚖ 248 KB

Alcohols 4\_ and s prepared from 3 underwent completely stereospecific etherification to give l-oxacephams 2 and s which were converted into the 1-oxacephem nucleus 2 via kaand lc. Functionalization at C-3' in 6 and &was unsuccessful. Since 7a-methoxy-1-oxacephem & (6059-S) was found to be a highly

Studies on β-lactam antibiotics. I. A no
Studies on β-lactam antibiotics. I. A novel conversion of penicillins into cephalosporins
✍ Takashi Kamiya; Tsutomu Teraji; Yoshihisa Saito; Masashi Hashimoto; Osamu Nakagu 📂 Article 📅 1973 🏛 Elsevier Science 🌐 French ⚖ 217 KB

The sulfenic acid intermediate (A) formed by a thermal sigmatropic rearrangement of penicillin sulfoxides (I) has been trapped either intramolecularly or intermolecularly by several methods. 1) Our efforts have been directed to the preparation of a key intermediate useful for syntheses of modified B