Synthetic studies on β-lactam antibiotic
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Tsutomu Aoki; Mitsuru Yoshioka; Yuji Sendo; Wataru Nagata
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Article
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1979
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Elsevier Science
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French
⚖ 248 KB
Alcohols 4\_ and s prepared from 3 underwent completely stereospecific etherification to give l-oxacephams 2 and s which were converted into the 1-oxacephem nucleus 2 via kaand lc. Functionalization at C-3' in 6 and &was unsuccessful. Since 7a-methoxy-1-oxacephem & (6059-S) was found to be a highly