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Synthetic Studies on the HIJK-Ring Fragment of Ciguatoxin

โœ Scribed by Tong-Zhu Liu; Minoru Isobe


Book ID
108370879
Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
250 KB
Volume
56
Category
Article
ISSN
0040-4020

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A stereoselective synthesis of the EFGH ring fragment of ciguatoxin CTX3C has been achieved through: (i) selective cleavage of a dioxepane acetal C O bond; (ii) radical cyclization to form the oxepane G ring; and (iii) chemoselective ring-closing metathesis of a triene yielding the hexahydrooxonin F