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Synthesis of the JKLM-ring fragment of ciguatoxin

✍ Scribed by Takayuki Baba; Guobin Huang; Minoru Isobe


Book ID
104205510
Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
591 KB
Volume
59
Category
Article
ISSN
0040-4020

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Convergent synthesis of the EFGH ring fr
✍ Hiroto Imai; Hisatoshi Uehara; Masayuki Inoue; Hiroki Oguri; Tohru Oishi; Masahi πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 95 KB

A stereoselective synthesis of the EFGH ring fragment of ciguatoxin CTX3C has been achieved through: (i) selective cleavage of a dioxepane acetal C O bond; (ii) radical cyclization to form the oxepane G ring; and (iii) chemoselective ring-closing metathesis of a triene yielding the hexahydrooxonin F