Synthetic studies on teleocidin IV. An efficient synthesis of (-)-indolactam V
β Scribed by Shin-ichi Nakatsuka; Toshiya Masuda; Kunisaku Sakai; Toshio Goto
- Book ID
- 104219391
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 230 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
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The same substituent to teleocidin B at 6-and 7-positions of indole nucleus was introduced via intramolecular cyclization and oxidative cleavage of C-N bond at l-position starting from simple indole. Teleocidin B (k) 2) 1s one of the most interesting natural products because of its potent biological
Indolactam-V, which shares the same partial structure of teleocidins A and B, shows a weak promoting activity compared to teleocidins. It suggests that the hydrophobic moieties substituted on the 6,7positions of teleocidins play a role in increasing the biological activity. 7-Substituted indolacta