✦ LIBER ✦
Synthetic studies on teleocidin II. Synthesis of indole derivatives containing the same substituent to teleocidin bat 6- and 7-positions of indole nucleus.
✍ Scribed by Shin-ichi Nakatsuka; Toshiya Masuda; Toshio Goto
- Book ID
- 104219521
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 240 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
The same substituent to teleocidin B at 6-and 7-positions of indole nucleus was introduced via intramolecular cyclization and oxidative cleavage of C-N bond at l-position starting from simple indole. Teleocidin B (k) 2) 1s one of the most interesting natural products because of its potent biological activity as tumor promoter and unique structures possessing highly substituted indole nucleus.
Recently, many synthetic studies2' toward it have been reported but no total synthesis is reported.