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Synthetic studies on Rabdosia diterpene lactones I: The preparation of a key tricyclic intermediate

✍ Scribed by Martin J. Kenny; Lewis N. Mander; S.Paul Sethi


Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
230 KB
Volume
27
Category
Article
ISSN
0040-4039

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✦ Synopsis


A strategy is proposed for the synthesis of Rabdosia diterpene lactones, eg. effusin 2 and the preparation of a suitable tricyclic intermedia= 6 described.


πŸ“œ SIMILAR VOLUMES


Synthetic studies on rabdosia diterpene
✍ M.J. Kenny; L.N. Mander; S.P. Sethi πŸ“‚ Article πŸ“… 1986 πŸ› Elsevier Science 🌐 French βš– 270 KB

The tricyclic ester 1 was transformed by a sequence of intramolecular Michael and alkylation reactions into the pentacyclic lactone 10 from which the (+)-15-desoxy derivatives of longikaurin C 2 and effusin 4 were then prepared.

Studies on the preparation of the β€œZiegl
✍ M. Leclaire; R. Levet; F. PΓ©ricaud; L. Ricard; J.Y. Lallemand πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 French βš– 885 KB

Preparation of the "Ziegler key intermediate" 2from lactone 3, readily obtained from hydroxy-O-ionone, was studied. In a first exploratory approach, lactones 11 and 13 were obtained but further transformations aimed at setting the ring junction were unsuccessful due to unexpected rearrangements. Thr

Studies for a Diastereoselective Synthes
✍ Marco Berettoni; Rinaldo Marini Bettolo; Vittorio Montanari; Teresa Prencipe; Se πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 German βš– 585 KB

In the course of the cited synthesis of (\*)-la, compound 3a was in fact obtained as a major epimer, along with 3b. The synthesis of (&)-la was then carried on with the minor epimer 3b [4].