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Synthetic studies on maduropeptin chromophore 1. Construction of the aryl ether and attempted synthesis of the [7.3.0] bicyclic system

✍ Scribed by K.C. Nicolaou; Kazunori Koide

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 220 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)00723-5

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✦ Synopsis

The aryl ether system of the maduropeptin chromophore artifact I was constructed via an aldol type condensation (7+6, Schemes 1 and 2, 7+19, Scheme 4), but attempted synthesis and ring closure of aldehyde 25 (Scheme 4) to afford the enediyne core of 1 failed.

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