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Synthetic Studies of Trichloroleucine Marine Natural Products. Michael Addition of LiCCl 3 to N -Crotonylcamphor Sultam

โœ Scribed by Brantley, Sarah E.; Molinski, Tadeusz F.


Book ID
126980904
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
48 KB
Volume
1
Category
Article
ISSN
1523-7060

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The Michael addition of N-(tert-butoxycarbonyl)-2-(tert-butyldimethylsiloxy)-3-methyl-pyrrole (4) to several a-methylene lactones catalyzed by fluoride ions yielded the corresponding homologated products (26-30) with good yields. Application of this reaction to the sililoxy bicyclic lactone (5) allo