Synthetic studies towards (+)-Dihydroamp
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Isabel Marcos; Elena Redero; Francisco Bermejo
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Article
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2000
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Elsevier Science
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French
โ 106 KB
The Michael addition of N-(tert-butoxycarbonyl)-2-(tert-butyldimethylsiloxy)-3-methyl-pyrrole (4) to several a-methylene lactones catalyzed by fluoride ions yielded the corresponding homologated products (26-30) with good yields. Application of this reaction to the sililoxy bicyclic lactone (5) allo