ChemInform Abstract: Synthetic Studies Towards (+)-Dihydroampullicin. Michael Addition of N-Boc-2-(tert-butyldimethylsiloxy)-3-methyl-pyrrole to α-Methylene Lactones.

Synthetic studies towards (+)-Dihydroamp

Synthetic studies towards (+)-Dihydroampullicin. Michael addition of N-Boc-2-(tert-butyldimethylsiloxy)-3-methyl-pyrrole to α-methylene lactones

✍ Isabel Marcos; Elena Redero; Francisco Bermejo 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 106 KB

The Michael addition of N-(tert-butoxycarbonyl)-2-(tert-butyldimethylsiloxy)-3-methyl-pyrrole (4) to several a-methylene lactones catalyzed by fluoride ions yielded the corresponding homologated products (26-30) with good yields. Application of this reaction to the sililoxy bicyclic lactone (5) allo