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Synthetic Studies of Tedanolide, a Marine Macrolide Displaying Potent Antitumor Activity. Stereoselective Synthesis of the C(13)−C(23) Segment

✍ Scribed by Iwata, Yasuhiro; Tanino, Keiji; Miyashita, Masaaki


Book ID
115442147
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
84 KB
Volume
7
Category
Article
ISSN
1523-7060

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✍ Arun K Ghosh; Yong Wang 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 130 KB

A stereoselective synthesis of the C 17 ±C 28 segment of the potent antitumor macrolide, laulimalide has been accomplished. The key steps are a ring-closing ole®n metathesis to construct the dihydropyran unit, nucleophilic addition of an alkynyl anion to the Weinreb amide, stereoselective reduction