Synthetic studies of erythromycins. II. Enantiospecific synthesis of A C-10-C-13 segment of erythronolide a from D-ribose

✍ Scribed by Mitsuhiro Kinoshita; Masayuki Arai; Katsuhiko Tomooka; Masaya Nakata

• Publisher: Elsevier Science
• Year: 1986
• Tongue: French
• Weight: 266 KB
• Volume: 27
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)84382-8

✦ Synopsis

3, a C-10-C-13 synthetic segment of erythronolide A (lJ was enantiospecifically synthesized in sixteen steps and 8.3% overall yield from D-ribose.

The successful total synthesis of erythronolide A (A), aglycone of the medicinally important 14-membered macrolide antibiotic erythromycin A, has recently been achieved by two Harvard groups, 2,3 one of which succeeded during the final stages of their conquest of erythromycin A itself.

3 Other synthetic efforts have been announced. 4

In the studies