Synthetic studies of 1,7-dioxaspiro[5.5]undecan-4-ones
✍ Scribed by D.R. Williams; B.A. Barner
- Book ID
- 108381820
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- French
- Weight
- 219 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
Ketones 11a-c obtained by iterative alkylation of acetone N,N-dimethylhydrazone with iodides 6 and 8a,b or epoxide 9 followed by SiO 2 /H 2 O-induced cleavage of the hydrazone were quantitatively transformed into 1,6-dioxaspiro[4.6]undecanes 12a,c and 1,7-dioxaspiro[5.6]dodecanes 12b using Yb(OTf) 3
## Abstract Quick access to polyfunctional spiroketal (3__R__)‐4[(2__S__,6__R__,8__R__,10__S__)‐4,4‐bis(ethylthio)‐10‐hydroxy‐8‐(2‐hydroxyethyl)‐1,7‐dioxaspiro[5.5]undec‐2‐yl]butane‐1,3‐diol [(+)‐**19**] is now available through the stereoselective functionalization of enantiomerically pure protect