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An entry to 1,6-dioxaspiro[4.6]undecanes and 1,7-dioxaspiro[5.6]dodecanes

✍ Scribed by Anthony Ollivier; Marie-Eve Sinibaldi; Loïc Toupet; Mounir Traïkia; Isabelle Canet

Book ID
104097927
Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
591 KB
Volume
51
Category
Article
ISSN
0040-4039

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✦ Synopsis

Ketones 11a-c obtained by iterative alkylation of acetone N,N-dimethylhydrazone with iodides 6 and 8a,b or epoxide 9 followed by SiO 2 /H 2 O-induced cleavage of the hydrazone were quantitatively transformed into 1,6-dioxaspiro[4.6]undecanes 12a,c and 1,7-dioxaspiro[5.6]dodecanes 12b using Yb(OTf) 3 in CH 3 CN.

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