SYNTHETIC POTENTIALITIES OF THIOPHENE SYSTEMS IN HETEROCYCLIC SYNTHESIS: A NOVEL SYNTHESIS OF THIENO[2,3- b ]PYRIDINE DERIVATIVES
β Scribed by Mohareb, Rafat M.; Shams, Hoda Z.; Elkholy, Yehya M.; Azam, Rasha A.
- Book ID
- 126629233
- Publisher
- Taylor and Francis Group
- Year
- 1999
- Tongue
- English
- Weight
- 713 KB
- Volume
- 155
- Category
- Article
- ISSN
- 1042-6507
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π SIMILAR VOLUMES
## A simple route to the synthesis of the pharmaceutically important thieno[2,3-d]pyrimidine derivatives and of thieno[2,3-b]pyridine derivatives via the use of 5-amin0-3-phenylthiophene-2,Cdicarbonitrile (2) as a starting material is described.
## Abstract Treating 5β(4βphenylcarboxamido)β3βcyanoβ4βmethylpyridinβ2(1__H__)thione (**3**) with elemental sulfur yielded thienopyridine **4**. Compound **4** reacts with acrylonitrile to give isoquinoline **7**. Compound **7** was also, prepared from **3** and methylenemalononitrile. Reaction of