✦ LIBER ✦

Alkyl heterocycles in heterocyclic synthesis (II): Novel synthesis of isoquinoline, thiazolopyridine, and thieno[2,3-b]pyridine derivatives

✍ Scribed by Tarek M. Abu Elmaati

Publisher: Journal of Heterocyclic Chemistry
Year: 2004
Tongue: English
Weight: 57 KB
Volume: 41
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570410614

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Treating 5‐(4‐phenylcarboxamido)‐3‐cyano‐4‐methylpyridin‐2(1__H__)thione (3) with elemental sulfur yielded thienopyridine 4. Compound 4 reacts with acrylonitrile to give isoquinoline 7. Compound 7 was also, prepared from 3 and methylenemalononitrile. Reaction of 3 with dimethylacetylene dicarboxylate (DMAD) gave the pyridothiazole 9. Also, 3 reacted with N,N‐dimethylchloroacetamide (10) to afford compound 11 which further reacted with the reagents 12, 13 and 14 providing the thieno[2,3‐b]pyridine derivatives 15, 16 and 17 respectively.

📜 SIMILAR VOLUMES

Alkyl Heterocycles in Heterocyclic Synth

Alkyl Heterocycles in Heterocyclic Synthesis. Part 2. Novel Synthesis of Isoquinoline, Thiazolopyridine, and Thieno[2,3-b]pyridine Derivatives.

✍ Tarek M. Abu Elmaati 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 27 KB 👁 1 views

Nitriles in heterocyclic synthesis: A no

Nitriles in heterocyclic synthesis: A novel synthesis of some thieno[2,3-d]pyrimidine and thieno[2,3-b]pyridine derivatives

✍ Zaghloul El-Shahat Kandeel 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 344 KB 👁 2 views

## A simple route to the synthesis of the pharmaceutically important thieno[2,3-d]pyrimidine derivatives and of thieno[2,3-b]pyridine derivatives via the use of 5-amin0-3-phenylthiophene-2,Cdicarbonitrile (2) as a starting material is described.

Phenyl isothiocyanate in heterocyclic sy

Phenyl isothiocyanate in heterocyclic synthesis: Novel synthesis of thiazoles, thieno[2,3-b]pyridine, thiophene and thieno[3,2-c]pyridazine derivatives

✍ Rafat Milad Mohareb 📂 Article 📅 1992 🏛 Springer Vienna 🌐 English ⚖ 392 KB

ChemInform Abstract: Nitriles in Heteroc

ChemInform Abstract: Nitriles in Heterocyclic Synthesis: A Novel Synthesis of Some Thieno(2, 3-d)pyrimidine and Thieno(2,3-b)pyridine Derivatives.

✍ Z. E. KANDEEL 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

Condensed isoquinolines. 7.* Synthesis o

Condensed isoquinolines. 7.* Synthesis of derivatives of the new heterocyclic system thieno[3′,2′:5,6]-pyrimido[1,2-b]isoquinoline

✍ V. M. Kisel'; V. A. Kovtunenko; T. T. Kucherenko; A. K. Tyltin; F. S. Babichev 📂 Article 📅 1996 🏛 Springer US 🌐 English ⚖ 266 KB

Fluorine-Containing Heterocycles. Part 2

Fluorine-Containing Heterocycles. Part 2. Synthesis and Reactions of New Thieno[2,3-b]pyridine Derivatives Bearing Trifluoromethyl Group.

✍ Abdu E. Abdel-Rahman; Etify A. Bakhite; Elham A. Al-Taifi 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 34 KB 👁 2 views