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Synthetic peptides derived from the sequence of a lasso peptide microcin J25 show antibacterial activity

✍ Scribed by Rania Soudy; Liru Wang; Kamaljit Kaur

Book ID: 113495674
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 635 KB
Volume: 20
Category: Article
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2011.12.061

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## Abstract Microcin J25 is a potent antibacterial peptide produced by __Escherichia coli__ AY25. It displays a lasso structure, which consists of a knot involving an N‐terminal macrolactam ring through which the C‐terminal tail is threaded and sterically trapped. In this study, we rationally desig

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