Sequence Determinants Governing the Topo
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Rémi Ducasse; Kok-Phen Yan; Christophe Goulard; Alain Blond; Dr. Yanyan Li; Dr.
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Article
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2012
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John Wiley and Sons
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English
⚖ 727 KB
## Abstract Microcin J25 is a potent antibacterial peptide produced by __Escherichia coli__ AY25. It displays a lasso structure, which consists of a knot involving an N‐terminal macrolactam ring through which the C‐terminal tail is threaded and sterically trapped. In this study, we rationally desig