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Synthetic mucin fragments. Synthesis of a tetra- and two penta-saccharides containing the O-β-d-galactopyranosyl-(1→3)-O-(2-acetamido-2-deoxy-β-d-glucopyranosyl)-(1→3)-d-galactopyranose (“lacto-N-triose 1”) unit

✍ Scribed by Rakesh K. Jain; Katsunori Kohata; Saeed A. Abbas; Khushi L. Matta

Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
460 KB
Volume
182
Category
Article
ISSN
0008-6215

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✦ Synopsis

We have previously" described the synthesis and use, as a glycosyl donor, of 0-(2,3,4,6-tctra-0-acetyi_P-D-galactopyracetyi-2-deoxy-~-D-glucopyranosyl)-(1~3)-2,4,6-tri-O-acctyi-~-D-galactopyranosyl bromide (1). Since then, bromide 1 has proved to be a useful and versatile glycosyl donor for the synthesis of a variety of mucin-type, higher oligosaccharide fragments. As an illustration of this use, we herein describe the synthesis of benzyl O-~-D-galactopyranosyl-(l~3)-0-(2-acetamido-2-deoxy-~-~-glucopyranosyl)-( l--+3)-AC0 5r 500 1 2 R, R = CHC&OMe-4 3 R' , R' GE cnC6n,0Me-4

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