Synthetic inhibitors of interleukin-6 I: 2,3,7,8-tetrahydro-4-aryl-1H-cyclopent [e] imidazo [1,2-a]- pyridin-5(6H)-one and related compounds
β Scribed by Jayaram R. Tagat; Dennis V. Nazareno; Stuart W. McCombie; Beverly E. Barton; Jennifer Shortall; James Jackson
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 204 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0960-894X
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I211 Genbve 4 (5. V .86) ~ Comparative results on the reduction of 4,6,7,8-tetrahydro-7,7-dimethyl-2H-1 -benzopyran-2,5(3H)-diones 1 are reported. Hydride reduction (LiAIH, in EtzO or NaBH, in i-PrOH) affords 2,3,4,6,7,8-hexahydro-5H-l-benzopyran-5-ones 5 in 30-60 % isolated yield. Photochemical red
## Abstract The reaction of 1βarylβ3β(dimethylamino)β1βpropanones 1 with one equivalent of 4,5βdiaminoβ1__H__βpyrimidinβ6βones 2, in acidic medium, leads to the formation of 4βarylβ2,3,6,7βtetrahydroβ1__H__βpyrimido[4,5β__b__]β[1,4]diazepinβ6βones 3. The structure elucidation of the products is bas
Short pathways are described for the synthesis of a representative example of each of the 7,8-dihydroand 1,2,3,4-tetrahydro-1,6-naphthyridine-5(6H)-one ring systems from simple pyridine precursors. An attempted synthesis of the related 4,6-dihydro-1,6-naphthyridin-5(1H)-one ring system from a common