It was proposed recently that CEM CD4-positive T cells infected chronically by herpes simplex virus type 1 (HSV-1) and human immunodeficiency virus type 1 (HIV-1) (CEM(HSV/HIV)) may be used as a model for studying HIV/HSV interactions. To ascertain whether HSV-HIV coinfection of T lymphocytes has a
β¦ LIBER β¦
Synthetic CD4 exocyclics inhibit binding of human immunodeficiency virus type 1 envelope to CD4 and virus replication in T lymphocytes
β Scribed by Zhang, Xin; Gaubin, Muriel; Briant, Laurence; Srikantan, Vasantha; Murali, Ramachandran; Saragovi, Uri; Weiner, David; Devaux, Christian; Autiero, Monica; Piatier-Tonneau, Dominique
- Book ID
- 109901874
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 715 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1087-0156
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## Abstract Human immunodeficiency virus type 1 (HIVβ1) infection is characterized by a progressive decrease of CD4^+^ T cells accompanied by other immune dysfunctions. Telomerase is transiently activated in lymphocytes during activation and is able to compensate for the progressive telomeric loss