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Synthetic CD4 exocyclic peptides antagonize CD4 holoreceptor binding and T cell activation

✍ Scribed by Zhang, Xin; Piatier-Tonneau, Dominique; Auffray, Charles; Murali, Ramachandran; Mahapatra, Ajit; Zhang, Fuqing; Maier, Curtis C.; Saragovi, H.; Greene, Mark I.


Book ID
109903008
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
609 KB
Volume
14
Category
Article
ISSN
1087-0156

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CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta