𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthetic approaches towards the sulfonamide substituted-4,5-diaryl-4H-1,2,4-triazole-3-thiones

✍ Scribed by Latifeh Navidpour; Mohsen Amini; Abbas Shafiee

Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
508 KB
Volume
44
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

magnified image

A new series of 3‐alkylthio‐4,5‐diaryl‐4__H__‐1,2,4‐triazoles having a SO~2~NH~2~ substituent in the para‐position on one of the aryl rings (19/25) were prepared starting from the appropriate benzoic acid hydrazides (15/21). Reaction of the corresponding hydrazides with the appropriate isothiocyanates yielded 16/22, which were cyclized in basic media to give 4,5‐diaryl‐2,4‐dihydro‐3__H__‐1,2,4‐triazole‐3‐thiones 17/23. Alkylation of 17/23 afforded the alkylthio compounds 18/24. Final debenzylation was achieved with concentrated sulfuric acid to give the target sulfonamides 19/25.

📜 SIMILAR VOLUMES

Convenient way to 5-substituted 4-amino-
Convenient way to 5-substituted 4-amino-2,3-dihydro-4H-1,2,4-triazole-3-thiones
✍ Romualdas Smičius; Milda Malvina Burbuliene; Virginija Jakubkienė; Emilija Udrwė 📂 Article 📅 2007 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 362 KB

## Abstract magnified image Various 4‐amino‐2,3‐dihydro‐4__H__‐triazoles with aromatic, aliphatic and heterocyclic substituents at the C(5) position were synthesized from corresponding esters and thiocarbohydrazide. This method allows the synthesis these heterocycles in a short time and at reduced