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Synthetic approaches to 1,8-naphthyridine-2,5-dione compounds

✍ Scribed by Toufike Kanouni; Qing Dong; Benjamin Abelovski; Michael B. Wallace

Book ID
104098621
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
398 KB
Volume
52
Category
Article
ISSN
0040-4039

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✦ Synopsis

A novel, efficient route for the synthesis of 1,8-naphthyridine-2,5-dione compounds is reported. The synthetic scheme allows for diversification at the 4-position of the core, and it was utilized to develop a series of inhibitors for MEK kinase.

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