𝔖 Bobbio Scriptorium
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Synthetic approach to the cephalotaxine skeleton

✍ Scribed by Weinstein, Boris.; Craig, Alan R.


Book ID
120044963
Publisher
American Chemical Society
Year
1976
Tongue
English
Weight
591 KB
Volume
41
Category
Article
ISSN
0022-3263

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Oxidation of readily available aminonaphthols 7a and 7b with activated manganese dioxide gives palmarumycin analogues 8a and 8b in good yield. The related benzoquinone monoacetals 10a-c undergo cycloaddition with 3-methoxy-2-pyrone at high pressure to give adducts 12a-c, also possessing the palmarum