β Scribed by D. Z. Simon; S. Brookman; J. Beliveau; R. L. Salvador
No coin nor oath required. For personal study only.
Several monoamino bis(propynyloxy)benzenes were prepared by a Mannich reaction and tested for antifungal activity against Trichophyton schoenleini, T. mentagraphytes, T. tonsurans, Candida albicans, and Epidermophyton flocossum. In addition, the bis(propynyloxy)benzene intermediates were tested and comparisons were made with standing drugs. The intermediates were found to be the most active, although two Mannich bases possessed considerable activity.
π SIMILAR VOLUMES
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Easy Access to Antifungal Agents Vulvovaginal candidiasis is a common problem; at one time or another most women experience at least one episode of this bothersome condition. For the past several years, the pharmaceutical industry has convinced women that this condition is easily treated and th
Antifungal agents alter the function and morphology of Candida cell membranes and cell walls. We observed that brief (30 minute) exposure to either amphotericin B or clotrimazole inhibited the agglutination of Candida blastoconidia by murine bronchoalveolar lavage fluid. This inhibition required con