✦ LIBER ✦

Interaction betweenCandidaagglutinins and antifungal agents

✍ Scribed by John C. Lutz; Kenneth M. Nugent

Book ID: 104772783
Publisher: Springer Netherlands
Year: 1987
Tongue: English
Weight: 311 KB
Volume: 99
Category: Article
ISSN: 0301-486X
DOI: 10.1007/bf00436676

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✦ Synopsis

Antifungal agents alter the function and morphology of Candida cell membranes and cell walls. We observed that brief (30 minute) exposure to either amphotericin B or clotrimazole inhibited the agglutination of Candida blastoconidia by murine bronchoalveolar lavage fluid. This inhibition required continuous drug presence. Neither amphotericin nor clotrimazole inhibited Candida agglutination by concanavalin A or pooled human serum. These results demonstrate that antifungal drugs can produce rapid changes in the surface characteristics of some fungi.

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