Synthesis, Structure, and Properties of a Model for Galactose Oxidase
β Scribed by Whittaker, Mei M.; Duncan, Walter R.; Whittaker, James W.
- Book ID
- 121431061
- Publisher
- American Chemical Society
- Year
- 1996
- Tongue
- English
- Weight
- 260 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0020-1669
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π SIMILAR VOLUMES
## Abstract The active site of the enzyme galactose oxidase (GOase) contains squareβpyramidal monocopper site, one of whose ligands is a tyrosinate sideβchain that is oxidized to an unusually stable radical in the active enzyme. The structure of this nonβinnocent tyrosinate is unique in two ways. F
Galactose oxidase (GO) contains one copper ion at its active site and performs a two-electron oxidation of primary alcohols to aldehydes, coupled with a reduction of O 2 to eomer in 68 % yield. The entire sequence was performed in 24 linear steps from (S)-malic acid. The material thus obtained was s