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Synthesis, Structure and Hypoxic Cytotoxicity of 3-Amino-1,2,4-benzotriazine-1,4-dioxide Derivatives

✍ Scribed by Faqin Jiang; Qinjie Weng; Rong Sheng; Qing Xia; Qiaojun He; Bo Yang; Yongzhou Hu

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
326 KB
Volume
340
Category
Article
ISSN
0365-6233

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## Abstract A new series of 16 6‐chloro‐1,1‐dioxo‐7‐{4‐[(4‐R^1^‐phenyl)imino]‐4__H__‐3,1‐benzoxazin‐2‐yl}‐3‐(substituted amino)‐1,4,2‐benzodithiazines **7–22** was prepared in order to evaluate the cytotoxic activity against six human cancer cell lines. The structures of the new compounds were conf