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Synthesis, structure, and antimycobacterial activity of 6-[1(3H)-isobenzofuranylidenemethyl]purines and analogs

✍ Scribed by Morten Brændvang; Vebjørn Bakken; Lise-Lotte Gundersen


Book ID
108072702
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
256 KB
Volume
17
Category
Article
ISSN
0968-0896

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A series of alkyl 1-heteroaryl-1H-1,2,3-triazole-4-carboxylates 6a-u were synthesised in four steps from methyl (Z)-2-benzyloxycarbonylamino-3-(dimethylamino)prop-2-enoate (1) and heterocyclic amines 2a-s. Triazoles 6a-o were tested against antimycobacterial activity. For the most active compound, n