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Synthesis and antimycobacterial activity of alkyl 1-heteroaryl-1H-1,2,3-triazole-4-carboxylates

✍ Scribed by Boštjan Japelj; Simon Rečnik; Petra Čebašek; Branko Stanovnik; Jurij Svete

Publisher: Journal of Heterocyclic Chemistry
Year: 2005
Tongue: English
Weight: 132 KB
Volume: 42
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570420620

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✦ Synopsis

A series of alkyl 1-heteroaryl-1H-1,2,3-triazole-4-carboxylates 6a-u were synthesised in four steps from methyl (Z)-2-benzyloxycarbonylamino-3-(dimethylamino)prop-2-enoate (1) and heterocyclic amines 2a-s. Triazoles 6a-o were tested against antimycobacterial activity. For the most active compound, n-pentyl 1-(6phenylpyridazin-3-yl)-1H-1,2,3-triazole-4-carboxylate (6n), minimum inhibitory concentration 3.13 µg/ml was determined.

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