Synthesis, stability, and radiolytic decomposition of carbon-14 labeled MK0677

✍ Scribed by A.N. Jones; D.C. Dean; H.J. Jenkins; D.G. Melillo; R.P. Nargund; M.A. Wallace

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: French
• Weight: 290 KB
• Volume: 38
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/(sici)1099-1344(199606)38:6<561::aid-jlcr872>3.0.co;2-s

✦ Synopsis

h4K0677 is an orally active growth hormone secretagogue. The crystallized carbon-14 labeled material was found to undergo radiolytic .decomposition via a peroxide intermediate which resulted in loss of the benzyl group. The rate was diminished when the tracer was crystallized from nitrogen-degassed solvents. Storage stability was best in aqueous ethanol.