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Synthesis of carbon-14 labelled NK-1 receptor antagonists GR203040 and GR205171

โœ Scribed by Karl M. Cable; Guy N. Wells; Derek R. Sutherland


Publisher
John Wiley and Sons
Year
2000
Tongue
French
Weight
469 KB
Volume
43
Category
Article
ISSN
0022-2135

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The synthesis in eight steps of the title compound from the commercially available[2O-"C]pregnenolone 1 is described. ## The expected I-[4-methyl-3-oxo-4-aza-5a-androstane-17~-[14C]carbonyl]-1,3-diisopropylurea ([14C]FCE 26073) was obtained with a radiochemical purity higher than 97% and a specif