Synthesis, Resolution, and Absolute Stereochemistry of (-)-Blestriarene C.
โ Scribed by Tetsutaro Hattori; Yuhi Shimazumi; Hitoshi Goto; Osamu Yamabe; Naoya Morohashi; Wataru Kawai; Sotaro Miyano
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 59 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The structure and absolute stereochemistry of thysanone 3 , a fungal benzoisochromanquinone with potent human rhbzovirus 3C-protease #zhibitoo" activity, is established by the total synthesis of its antipode I from (S)-propylene oxide.
Reduction of 3-(dialkylamino)-1-aryl-t-propanones with a 2:l complex of [(2R,3S-(+)-4--dimethylamino-1,2-diphenyl-3-methyl-2-butanol] (8) and lithium aluminum hydride (LAH) provided the corresponding 1,Saminoalcohols in high ee's (SO-88%). This process was developed and applied to the synthesis of L