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โœฆ   LIBER   โœฆ

Synthesis and absolute stereochemistry of thysanone

โœ Scribed by Christopher D. Donner; Melvyn Gill


Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
172 KB
Volume
40
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


The structure and absolute stereochemistry of thysanone 3 , a fungal benzoisochromanquinone with potent human rhbzovirus 3C-protease #zhibitoo" activity, is established by the total synthesis of its antipode I from (S)-propylene oxide.


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Asymmetric synthesis and absolute stereo
โœ Jack Deeter; Jeff Frazier; Gilbert Staten; Mike Staszak; Leland Weigel ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 331 KB

Reduction of 3-(dialkylamino)-1-aryl-t-propanones with a 2:l complex of [(2R,3S-(+)-4--dimethylamino-1,2-diphenyl-3-methyl-2-butanol] (8) and lithium aluminum hydride (LAH) provided the corresponding 1,Saminoalcohols in high ee's (SO-88%). This process was developed and applied to the synthesis of L