✦ LIBER ✦

Synthesis, resolution and absolute configuration of trans 4,5-diphenyl-pyrrolidin-2-one: a possible chiral auxiliary

✍ Scribed by Jaime Escalante; Miguel A. González-Tototzin

Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 379 KB
Volume: 14
Category: Article
ISSN: 0957-4166
DOI: 10.1016/s0957-4166(03)00097-1

No coin nor oath required. For personal study only.

✦ Synopsis

b-Lactam (±)-N-benzyl-4-phenyl-azetidin-2-one rac-6a was converted into the g-lactam (±)-trans-4,5-diphenyl-pyrrolidin-2-one rac-5 which was resolved via the preparation of diastereomers with N-phthalyl-L-alanine chloride or D-alanine chloride and its absolute configuration was determined by X-ray crystallographic analysis. This heterocycle has potential as a chiral g-lactam in asymmetric induction due to the steric effects of its phenyl groups.

📜 SIMILAR VOLUMES

A practical one-pot synthesis of trans-4

A practical one-pot synthesis of trans-4,5-disubstituted 2-pyrrolidinones and the related pyrrolidines

✍ Nathan K. Yee 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 244 KB

A practical and general method for the st©reoselective synthesis of trans-4,5-dis~tituted 2-pyrrolidinones was developed. Hydride reduction of these pyrrolidinones gave the corresponding pyrrolidines.

ChemInform Abstract: A Practical One-Pot

ChemInform Abstract: A Practical One-Pot Synthesis of trans-4,5-Disubstituted 2- Pyrrolidinones and the Related Pyrrolidines.

✍ N. K. YEE 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB 👁 2 views

Resolution and absolute configuration of

Resolution and absolute configuration of trans (+)- and (−)-6-hydroxymethyl-2-methoxy-5,6-dihydro-2H-pyrans, substrates for total synthesis of monosaccharides

✍ A. Konowal̵; J. Jurczak; A. Zamojski 📂 Article 📅 1976 🏛 Elsevier Science 🌐 French ⚖ 303 KB

ChemInform Abstract: Highly Effective an

ChemInform Abstract: Highly Effective and Recyclable Chiral Auxiliaries: A Study of the Synthesis and Use of Three 4-Isopropyl-5,5-diaryloxazolidin-2-ones.

✍ Karen Alexander; Stuart Cook; Colin L. Gibson; Alan R. Kennedy 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 36 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Melatonin receptor agents: Synthesis, re

Melatonin receptor agents: Synthesis, resolution by HPLC on polysaccharides chiral stationary phases, absolute configuration, and pharmacology of the enantiomers of (±)-N-[2-(7-fluoro-1,2,3,4- tetrahydronaphthalen-1-yl)ethyl]acetamide

✍ Emmanuelle Lipka-Belloli; Abdelhalim Guelzim; Said Yous; Jacques Lefebvre; Carol 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 159 KB 👁 2 views

ChemInform Abstract: Heterogenized Catal

ChemInform Abstract: Heterogenized Catalysts on Zeolites. Synthesis of New Chiral Rh(I) Complexes with (2S,4R)-trans-4-RCOO-2-(t-butylaminocarbonyl)pyrrolidines and (2S,4R)-cis-4-RCONH-2-(t-butylaminocarbonyl)pyrrolidines. Heterogenization on Silica and a USY-Zeolite and Study of the Role of Support on Their Catalytic Profile in Hydrogenation of Olefins.

✍ A. CORMA; M. IGLESIAS; F. MOHINO; F. SANCHEZ 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 2 views