A practical one-pot synthesis of trans-4,5-disubstituted 2-pyrrolidinones and the related pyrrolidines
β Scribed by Nathan K. Yee
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 244 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
A practical and general method for the stΒ©reoselective synthesis of trans-4,5-dis~tituted 2-pyrrolidinones was developed. Hydride reduction of these pyrrolidinones gave the corresponding pyrrolidines.
π SIMILAR VOLUMES
We present a modular synthesis of a new class of chiral N,Nchelating ligands containing the C2-symmetric trans-2,5-disubstituted pyrrolidine moiety linked to a pyridine ring. (-)-2-[(2R,5R)-2,5-Dimethylpyrrolidin-l-ylmethyl]pyridine (11, (R,R)-MePMP), (-)-2-[2-((2R,5R)-2,5-dimethylpyrrolidin-l-yl)et
Practical Synthesis of an Enantiomerically Pure trans-4,5-Disubstituted 2-Pyrrolidinone via Enzymatic Resolution. Preparation of the LTB 4 Inhibitor BIRZ-227. -The efficient synthesis of rac. (II) in a simple one-pot procedure was already described. A novel enzymatic resolution of its rac derivative
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